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KMID : 0361020090520090724
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Korean Journal of Otolaryngology - Head and Neck Surgery
2009 Volume.52 No. 9 p.724 ~ p.729
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Changes in the Regional Cerebral Blood Flow in Postlingual Deaf Patients Measured by ECD-SPECT: Preliminary Study
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Han Min-Ah
Yeo Sang-Won
Yang Dong-Won
Chung Yong-An
Park Kyoung-Ho
Choi Hyeog-Gi
Kim Sung-Hoon
Park Shi-Nae
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Abstract
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Background and Objectives: Cochlear implantation improves hearing ability in adults with profound deafness. Using non-invasive functional brain imaging methods, it is now possible to assess regional blood flow and activity of auditory cortex which might be correlated to the outcome of cochlear implantation. The aim of this study was to measure the regional cerebral blood flow in patients with postlingual deafness utilizing controls in a variety of methods.
Subjects and Method: Six postlingual deaf adults who were planned to undertake cochlear implantation and 12 normal controls were examined with technetium-99m-labeled ethyl cysteinate dimer single-photon emission computed tomography (99mTc-ECD-SPECT). Images of the regional cerebral blood flow were processed by statistical parametric mapping and analyzed by unpaired t-test.
Results: The analysis of the SPECT images of the 6 deaf patients showed decreased cerebral blood flow in both superior, middle temporal and inferior prefrontal lobes compared with controls (p<0.001). Also this decreased auditory cortical blood flow was greater in left hemisphere in all patients.
Conclusion:The degree of remaining activity of auditory cortex and the lateralization of the dominant auditory hemisphere, which may influence on the outcome of cochlear implantation, could be measured by ECD-SPECT.
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KEYWORD
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Auditory cortex, Deaf·Postlingual, ECD-SPECT, Cochlear implantation
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